diff --git a/build_release_macos.sh b/build_release_macos.sh
index dffeb3d4b1..4fca109877 100755
--- a/build_release_macos.sh
+++ b/build_release_macos.sh
@@ -3,7 +3,7 @@
 set -e
 set -o pipefail
 
-while getopts ":dpa:snt:xbc:1Tuh" opt; do
+while getopts ":dpa:snt:xbc:i:1Tuh" opt; do
   case "${opt}" in
     d )
         export BUILD_TARGET="deps"
@@ -34,6 +34,9 @@ while getopts ":dpa:snt:xbc:1Tuh" opt; do
     c )
         export BUILD_CONFIG="$OPTARG"
         ;;
+    i )
+        export CMAKE_IGNORE_PREFIX_PATH="${CMAKE_IGNORE_PREFIX_PATH:+$CMAKE_IGNORE_PREFIX_PATH;}$OPTARG"
+        ;;
     1 )
         export CMAKE_BUILD_PARALLEL_LEVEL=1
         ;;
@@ -53,6 +56,7 @@ while getopts ":dpa:snt:xbc:1Tuh" opt; do
         echo "   -x: Use Ninja Multi-Config CMake generator, default is Xcode"
         echo "   -b: Build without reconfiguring CMake"
         echo "   -c: Set CMake build configuration, default is Release"
+        echo "   -i: Add a prefix to ignore during CMake dependency discovery (repeatable), defaults to /opt/local:/usr/local:/opt/homebrew"
         echo "   -1: Use single job for building"
         echo "   -T: Build and run tests"
         exit 0
@@ -93,6 +97,10 @@ if [ -z "$OSX_DEPLOYMENT_TARGET" ]; then
   export OSX_DEPLOYMENT_TARGET="11.3"
 fi
 
+if [ -z "$CMAKE_IGNORE_PREFIX_PATH" ]; then
+  export CMAKE_IGNORE_PREFIX_PATH="/opt/local:/usr/local:/opt/homebrew"
+fi
+
 CMAKE_VERSION=$(cmake --version | head -1 | sed 's/[^0-9]*\([0-9]*\).*/\1/')
 if [ "$CMAKE_VERSION" -ge 4 ] 2>/dev/null; then
   export CMAKE_POLICY_VERSION_MINIMUM=3.5
@@ -108,6 +116,7 @@ echo " - BUILD_CONFIG: $BUILD_CONFIG"
 echo " - BUILD_TARGET: $BUILD_TARGET"
 echo " - CMAKE_GENERATOR: $SLICER_CMAKE_GENERATOR for Slicer, $DEPS_CMAKE_GENERATOR for deps"
 echo " - OSX_DEPLOYMENT_TARGET: $OSX_DEPLOYMENT_TARGET"
+echo " - CMAKE_IGNORE_PREFIX_PATH: $CMAKE_IGNORE_PREFIX_PATH"
 echo
 
 # if which -s brew; then
@@ -151,6 +160,7 @@ function build_deps() {
                         -DCMAKE_BUILD_TYPE="$BUILD_CONFIG" \
                         -DCMAKE_OSX_ARCHITECTURES:STRING="${_ARCH}" \
                         -DCMAKE_OSX_DEPLOYMENT_TARGET="${OSX_DEPLOYMENT_TARGET}" \
+                        -DCMAKE_IGNORE_PREFIX_PATH="${CMAKE_IGNORE_PREFIX_PATH}" \
                         ${CMAKE_POLICY_COMPAT}
                 fi
                 cmake --build . --config "$BUILD_CONFIG" --target deps
@@ -192,6 +202,7 @@ function build_slicer() {
                     -DCMAKE_BUILD_TYPE="$BUILD_CONFIG" \
                     -DCMAKE_OSX_ARCHITECTURES="${_ARCH}" \
                     -DCMAKE_OSX_DEPLOYMENT_TARGET="${OSX_DEPLOYMENT_TARGET}" \
+                    -DCMAKE_IGNORE_PREFIX_PATH="${CMAKE_IGNORE_PREFIX_PATH}" \
                     ${CMAKE_POLICY_COMPAT}
             fi
             cmake --build . --config "$BUILD_CONFIG" --target "$SLICER_BUILD_TARGET"
diff --git a/deps/CMakeLists.txt b/deps/CMakeLists.txt
index 1826c029d0..a90de994db 100644
--- a/deps/CMakeLists.txt
+++ b/deps/CMakeLists.txt
@@ -185,6 +185,7 @@ if (NOT IS_CROSS_COMPILE OR NOT APPLE)
             -DCMAKE_INSTALL_PREFIX:STRING=${DESTDIR}
             -DCMAKE_MODULE_PATH:STRING=${PROJECT_SOURCE_DIR}/../cmake/modules
             -DCMAKE_PREFIX_PATH:STRING=${DESTDIR}
+            -DCMAKE_IGNORE_PREFIX_PATH:STRING=${CMAKE_IGNORE_PREFIX_PATH}
             -DCMAKE_DEBUG_POSTFIX:STRING=d
             -DCMAKE_C_COMPILER:STRING=${CMAKE_C_COMPILER}
             -DCMAKE_CXX_COMPILER:STRING=${CMAKE_CXX_COMPILER}
@@ -232,6 +233,7 @@ else()
             -DCMAKE_POLICY_VERSION_MINIMUM=3.5
             -DCMAKE_INSTALL_PREFIX:STRING=${DESTDIR}
             -DCMAKE_PREFIX_PATH:STRING=${DESTDIR}
+            -DCMAKE_IGNORE_PREFIX_PATH:STRING=${CMAKE_IGNORE_PREFIX_PATH}
             -DBUILD_SHARED_LIBS:BOOL=OFF
             ${_cmake_osx_arch}
             "${_configs_line}"